{"id":2622,"date":"2020-04-09T03:53:27","date_gmt":"2020-04-09T11:53:27","guid":{"rendered":"http:\/\/thomas-hopp.com\/blog\/?p=2622"},"modified":"2023-08-12T06:16:36","modified_gmt":"2023-08-12T14:16:36","slug":"formulating-covid-19-synthetic-vaccine-doses","status":"publish","type":"post","link":"http:\/\/thomas-hopp.com\/blog\/2020\/04\/09\/formulating-covid-19-synthetic-vaccine-doses\/","title":{"rendered":"Formulating COVID-19 Synthetic Vaccine Doses"},"content":{"rendered":"

\"\"<\/a>This is my third and final post describing a COVID-19 synthetic vaccine. Future posts will return to the usual fare of books, stories, and anecdotes. But this last serious post wraps up a full disclosure of how to make a COVID-19 vaccine, so here goes.<\/p>\n

The thing is, you can\u2019t just make<\/em> a vaccine. You have to inject it, and it has to immunize. So the last step in this process is called formulation. I\u2019ve formulated injectables for\u2013let\u2019s see\u2013about 47 years now, so I ought to know how. Shown at left is a photo of the most recent vaccine I worked on, an anti-cancer vaccine targeting the hormone hCG (there are links below for more information about it).<\/p>\n

\"\"<\/a>But before I get into formulation details, let me show you just how well these vaccines work. The graph at right shows an hCG synthetic-peptide vaccination (black arrow) that raised high levels of anti-cancer antibodies within just three weeks and increased by a thousand-fold a few weeks after that. High antibody levels persisted for six months and probably lasted more than a year, though the experiment was ended before that. The two white insets show ISMS (injection site macro-pathology scores) at or below 1.0, which the FDA defines as very little ouch<\/em> going on. Wouldn\u2019t you like to be protected for six months to a year from COVID-19 right about now? I know I would. By next year, COVID-19 may have done its damage and disappeared, only to be replaced by some new threat coming along. No worries though, we can always make a whole new synthetic peptide targeting the next microbe in three days.<\/p>\n

All vaccines are formulated with some added materials (adjuvants) that aid the immune response by creating a depot of material that stays at the injection site for weeks or months. All the while white blood cells come and go, getting more and more riled up and producing more and more antibodies. There are dozens of formulation components out there, and most immunology labs have some on hand. I\u2019ve used quite a number of them myself. Things like alum, squalene oil, gels, and mineral powders, plus immunostimulants like muramyl dipeptide or cytokines thrown in for good measure. It\u2019s a bit of a grab bag of possibilities, but most immunology labs have these things or can get them. The slowest step is to test them in a quality assurance (QA) program to guarantee their safety\u2013but what I\u2019m talking about here assumes you\u2019ve already got the materials certified clean and ready-to-go.<\/p>\n

So let me be specific here, because there are many ways to do things wrong, and only a few ways to get the right blend of immune-enhancing ingredients. Here\u2019s my favorite formula (you can skip this part if you don\u2019t have a PhD in biochemistry):<\/p>\n

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  1. Solid immunogen<\/li>\n<\/ol>\n