Omega-3 oils, resolvins, and protectins

Resolvin D2As a biochemist researching a medical thriller novel, I find some interesting science while doing my background research. While getting information about whale oil for The Neah Virus, I came across some unexpected information. How about an entirely new insight into inflammation, allergy, and arthritis, and new ways to treat them? That’s what I’m onto.

Scientists have known for decades that the American diet is deficient in certain healthy oils and overloaded with other not-so-healthy oils. The end result of this imbalance is early death from hardening of the arteries, which is an inflammatory condition, and lots of suffering from the pain of arthritis and the swelling of allergy.

In response, health-food advocates and medical professionals have for several decades recommended people get more omega-3 fatty acids in their diets by eating the right foods or taking supplements in pill form. They have also suggested that a dose of baby aspirin every day also helps dampen inflammation.

Well, what’s new is the discovery in the year 2000 of exactly how these supplements and pills work. They cause your body to produce resolvins and protectins.

Whatins and whoseins, you say?

Omega-3 DHAThe image at the top of this note is a chemical schematic of resolvin D2, one of a group of molecules produced by your body to help “resolve” inflammation. These beneficial oils are only produced in sufficient quantity when enough omega-3 fats are around to make them from (one of these omega-3s, docosahexaenoic acid or DHA, is shown at right).

Here’s the cool thing that’s just been discovered in the last few years: aspirin interacts with the enzyme in your body that converts DHA to resolvins. This science is so new that nobody seems to have gotten on the health-food bandwagon about it yet. I’m somewhere near the first to “get it” and that’s only because I have five years of PhD training at Cornell Medical College under my belt and a lifetime in the lab.

The researchers who have spearheaded studies of resolvins and protectins (similar molecules that stop brain inflammation) seem as amazed as I am at their findings. Suddenly, decades of knowledge that omega-3 oils and aspirin are good for inflammation sufferers have come together, and even more powerful beneficial molecules have been identified.

So what am I gonna do about it? I’m gonna take more omega-3 supplement pills than I used to, and keep taking that baby aspirin daily. At least now I know why I’m doing it.

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Help me judge my book’s new cover

NeahVirusCoverPeople often judge a book by its cover, but here’s your chance to judge my next book’s cover before it’s even published! In contravention to all manner of advice I have always made my own covers, in keeping with my fiercely independent nature when it comes to authorship. My cover for The Neah Virus, my latest medical thriller novel, is no exception. So I’m wondering, how do you like it so far?

I developed the picture from my research on the sculpture and artwork of Pacific Northwest native people. The two-headed sea serpent is a spirit animal that figures in legends up and down the North Pacific coast. It is said to have great medical power, suggesting it might be related to the ancient Greek caduceus, the winged staff with two twined serpents carried by the medicine god Mercury, which in recent times has become the symbol of the medical profession.

NeavVirusCover2Folks I have spoken to in Neah Bay say Makah tribal lore doesn’t include a creature comparable to the Alaskan Kwakiutl’s Sisiutl or the Tamallay of the Quinaults to the south. However, Makahs are quite familiar with a pair of Lightning Snakes who help Thunderbird on his whale hunts. Furthermore, a 500-year-old carving of a two-headed serpent was unearthed in a Makah archeological dig.

Anyway, enough about the serpent. How about the cover? I’d love to get some opinions before it’s finalized. If you’d like to have a say in my next book’s cover, now is the time. You can comment on this post below or find an email contact by clicking on the “website” link just under my smiling face above.

You can see I duded up the first image to make the second image a little more three dimensional. But does that help? I’m not sure. Click the images to see larger versions. The first is a little more stark and that seems like a good cover for a medical thriller where the stark terror of a deadly disease awaits within the pages.

So let me know which you prefer. Or, let me know if you’d prefer something else.

I’m all eyes and ears. So is the serpent.

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Edit, edit, edit

Neah Virus Cover DraftI’m in the last throes of editing my new medical thriller, The Neah Virus. Chapter 23 of 25 in a second major revision. The home stretch.

It’s tough duty but it’s got to be done. My daily ritual of writing starts sometimes as early as 3:45 AM and can last deep into happy hour.

The image is a draft cover for the ebook. Like the text, it will get quite a bit of editing before all is said and done.

Some things seem certain, however. For instance, the notion of a virus that spares Makah Indians but kills all the rest of us is a given. The idea that a mysterious two-headed serpent spirit is involved, is a given. The concept that the super-intelligent biomedical researcher hero, Dr. Peyton McKean, will be involved in trying to cure the disease before it gets him and all of us, is the big question. Can he come up with a solution before we all become fevered, crazed maniacs? Or will modern society crumble in the face of a threat from a virus that is centuries old?

That sort of thing. Anyway. Back to editing.

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Mars Rovers Attack!

Death from Mars

Surrender Earth or Die!

Earthlings everywhere were horrified today to learn that gigantic machines from Mars have landed on our planet and begun a war of conquest. After decades of one-sided spacecraft invasion from Earth to Mars, the otherwise peaceful, but very tiny residents of the Red Planet have retaliated with a fleet of stupendous six-wheeled machines, which have landed on every continent and engaged the armed forces of an unprepared world. The outcome is still very much in doubt.

The photo above, taken by a news correspondent in Pecos, Texas, shows one of the towering machines engaging a tank troop from nearby Fort Bliss. Needless to say, the action went poorly for the humans. Opening up with laser blasts from its eyes, the machine devastated its opposition and went on to roll over the news photographer. A mechanical voice from the charging machine challenged, “Let’s see how you like getting run over like you have done to us for years!”

The Pentagon, the President, and an elite group of planetary scientists issued the following statement: “We deeply regret the loss of life. We have established a committee to protest to the Martians, if we can find them.”

Martians, it turns out, are human shaped but about the size of bacteria. Our robotic rovers, moving about on their planet, have caused havoc on a scale only imaginable if one is 1/60,000th of an inch tall. Whole Martian cities have been annihilated under the six rolling wheels of our planetary rovers. The Martians attempted to retaliate with their minuscule thermonuclear devices, which hardly slowed the march of our machines across their homes and cities. 7,219 Martian nations have banded together to create these immense machines and launch them to earth.

A radioed statement was received from a group calling itself the United Nations of Gree-wah-noo-noo, just as the first landers dropped onto their terrestrial landing ellipses. It translates, “Take that, you big meanies!”

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Roamin’ Sonoma

WinelandsThe writing life is tough. Even vacations can be tangled in the web of story, character, and plot. This vacation is no exception. Driven by the need for knowledge and verisimilitude for my upcoming short story, “High Stone Chateau,” I have once again trekked with Shelley into an environment filled with intriguing culture, atmospheric climate, and mysterious backroads and byways. By all that, I mean that we have flown from the rain and cold of Seattle to the warmth and bliss of Sonoma County wine country in California.

I know. I know. You’re going to say, “Aw, poor little Tommy. Does him have to suffer in that hot sun all day? Does him have to wear him sun hat to keep mean old Mr. Sun off him head? Does him have to slurp wine until him might fall over? Poor beebee!”

And that’s just it. Here I am, sitting around by the pool, bathed in the glare of that unfamiliar object in the sky, fearful of getting a burn on my tender white hide, feeling compelled to have another sip. It’s tough duty, but I intend to prevail.

Hopefully, when all my suffering is done, “High Stone Chateau” will have some of that “Je ne sais quoi” that makes a good mystery story so intoxicating.

God knows I’ve been through hell to create it.

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Writers of Mystery

Would you like to spend some time with notorious mystery authors of the Pacific Northwest? Here are a couple of chances to do so.

I belong to the Pacific Northwest chapter of the Mystery Writers of America, the most prestigious gathering of mystery writers on the globe. Our local group of writers and readers of mystery fiction meet monthly, usually on the second saturday, to eat, drink, and listen to some pretty enthralling speakers. We host famous authors, law enforcement people, crime scene investigators and other players in the never-ending cavalcade of crime reality and fiction. You always learn something new and useful at an MWA NW meeting.

And tonight is no exception. The Northwest chapter is hosting the annual Willo Davis Roberts award in mystery fiction, which this year goes to Northwest mystery author Earl Emerson. If you’re a fan of Emerson’s stories, you might want to drop everything else and make plans to join us tonight in Bellevue WA for the big event. Drop-ins can be accommodated for a small fee plus the price of dinner.

Here’s the announcement:

Join us Saturday evening, April 20, at Firenze restaurant near Bellevue as we celebrate the career of longtime Seattle-area writer Earl Emerson, author of the Thomas Black and Mac Fontana mystery series, and 27 novels in all. With an introduction from our own Leslie Adkins, an über-Emerson fan, Earl, a veteran Seattle firefighter and Shamus Award winner, will share his thoughts on the craft of writing, the appeal of the Northwest as a mystery locale, and the state of book publishing, among other topics. Join us at 6 p.m. for drinks and dinner with one of the most iconic figures in Northwest crime fiction. RSVP to MWA-Northwest board member David B. Schlosser at dbschlosser@analects-ink.com or 425-242-0162. Due to the size of the venue, attendance will be capped at 30, so place your RSVPs now!

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Triumph of the Toads

RibbitAs I write my medical thriller, The Neah Virus, I often draw on personal experience to flesh out characters and give them a sense of realism. Time and again I cast my memory back over decades in the biotechnology industry, and time and again I find myself remembering personalities of less-than-sterling quality.

I’m not saying that all, or even most, people working in the business are of low and mean nature, but it is disturbing to recall how often those of lesser talent found ways of circumventing, backstabbing or simply outlasting their intellectual betters. On reflection, it amazes me sometimes how any significant scientific discoveries ever happened in the biotech corporate cultures I have seen, given how much energy was wasted in conflict and political maneuvering.

I won’t mention any names, either of people or companies, and I won’t get too specific in details of old showdowns, but suffice it to say that my Peyton McKean mysteries almost always involve the kind of in-fighting I personally experienced years ago while simply trying to do my job as a scientist and get on with the business of scientific discovery. Here are a couple examples of personality types who made my job a lot more difficult than it had to be:

The sycophant. This is a classic corporate type and I can recall several from my early years in biotech. This is the guy (or gal) who always sees it the boss’s way. You would think the boss would get wise, but instead I have seen such ass-kissers go from minor players to top lieutenants, and even on to become heads of major corporations as years roll by. But here’s the problem. Every time I would debate the boss’s cherished–and often wrong–concepts for how to tackle a problem, the sycophant would argue with me and add to the boss’s certainty. The end result was that new personnel would be assigned to join the ranks of the sycophant’s research group while mine languished. And here’s the rub. More often than not, the boss’s plan would fail and my approach would succeed, and yet the sycophant would continue on with the larger research group. A neat trick. Fail while using the boss’s plan and enhance your standing anyway. Never fear though, I am not giving you a showcase of defeatism. I would often pursue my own disdained approach and solve the problem despite my lack of help or the boss’s approval along the way. The end result was corporate success with the project and my name featured prominently on a company patent with few co-authors.

This sort of thing happened quite a few times. I ultimately was the leader of the smallest but most productive laboratories in several organizations. Here’s another interesting character type:

The cry baby. After my discoveries had made me prominent in one biotech company, I began to take a certain kind of flack. I would be called to the big boss’s office for a browbeating about how my remarks at one meeting or another had upset some of my colleagues. As often as not, the boss refused to tell me who had complained, insisting that I might subject the plaintiff to more upsetting conversation. Of course, all I wanted was to make a direct apology and try to establish some sense of camaraderie. Often, the criticism was not about what I had said–perhaps a new way to approach a problem–but rather about how I had said it. Not politely enough for some people’s tastes, I guess.

The toady. Here’s one more quick one. I recall a particular man who, when playing up to his boss, actually bent down so low in voicing his flattery and obeisances, as to take on the actual posture of a toad.

I’d better stop or I’ll have an unending cavalcade of ne’er-do-wells to tell you about. Perhaps I’ll blog again someday about some more of these types.

There’s one nice thing about recalling these characters from my real-life past. If I get tired of writing about their odious ways in my stories, I can always concoct a scene in which they die horribly or are reduced to an ignominious end. In The Neah Virus, I’m glad to say, that happens more than once.

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The New Old Me

New Old TomIt’s been a decade or so since I updated my photos on the web. I guess it’s about time. As you can see, I’ve given up any pretense of youth and opted for the wise old man look. Or is that wizened old man? Either way you look at it (or me) it was high time.

In the near future, photos like the one emblazoned above this blog and the ones on my books’ back covers will be–shall we say–upgraded to version now-point-oh.

Shelley took this shot of me grinning in the back yard wearing my favorite green buffalo plaid shirt, which has born the ravages of time better than its wearer. With all that spring verdure gushing out in the forest behind me, there’s a balance between that which is blooming and that which is wilting. If you can stand it, click the image for a closer view.

I’m okay with all this white hair. Gandalf beware! Your status as first among wizards is under challenge. Mark Twain, I’ve got nearly as much white stuff sprouting out of me as you ever had except maybe out your nose and ears. So watch out. How can a body help but look erudite, wise, party-to-hidden-knowledge, and all those other traits of wizards, scientists and writers when one has such a snowy effusion all over one’s head?

Anyway, that’s how I like to think of it.

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Rediscovering the Lost Waterfall

TomByTheFallsIt’s wonderful when you discover a place of great natural beauty right in your own little corner of the world, a place hinted at in old stories and drawn on old maps but not seen by human eyes in the better part of a century. Such was my good fortune last weekend. The lost waterfall of Sahalie Ski Club has been rediscovered.

The Summit area of Snoqualmie Pass is a place heavily trammeled in summer and winter by hikers on foot and on snowshoes. And yet a waterfall of great beauty has gone unnoticed for decades until now. Dave Galvin, Sahalie Lodge’s master snowshoer, and I set out on a trek to find what had been hidden for many years.

I caught a glimpse of just the very top of the falls 37 years ago while bushwhacking alone through rugged backcountry, and caught that glimpse at great peril to my life. I had been following the trace of a handwritten scrawl on an old logging map of the area, moving through incredibly steep and rugged old-growth forest in terrain so dangerous that the logging companies had passed it by. In that forest, I came to the brink of a precipice about one-hundred feet tall, and I heard the roar of falling water. In order to see what was below, I got a good grip on a small hemlock sapling and leaned out over thin air to look down. There was a rock ledge about thirty feet below me with a stream launching off its precipice. I could see just the top ten feet or so of the falls, which then disappeared into a chasm whose bottom I couldn’t see.

The sapling was ready to come out of the ground by its roots and the slope beneath my feet was slippery with wet hemlock needles, so I retreated. Over the decades, when weather and time permitted, I took more hikes into the area trying to get at the falls from north, south, east, and west. Each assault was deadlocked by incredibly steep slippery slopes and a canyon that I like to call The Lost Valley.

DaveByTheFallsSo when Dave Galvin and I decided to make a try on the falls last weekend with ten feet of snow on the ground in the hopes that a way to the falls could be found, I had my doubts. We snowshoed our way up to Sahalie’s rockslide, skirted its avalanche zone, bypassed Bear’s Den Rock and the Frenchman’s Cabin, and tried to get at the falls from above. We plunged down into the canyon twice, and twice we had to struggle out again up slopes sometimes steeper than a snowshoe can handle. On those slopes, we did more floundering than hiking–at least I did.

Winded after two steep assaults and covered in powdery snow including some down my back and up my ying-yang, I was willing to just barely allow that maybe I would be defeated again. The Lost Falls would just have to remain lost. In fact, as we snowshoed downhill paralleling the gorge, I began to doubt my memory. Had I only dreamed of hanging off that twig above a breathtaking precipice?

Dave was not easily discouraged. He forged into the canyon again on a slope steeper than any before, down into a chasm deeper than any before, without even asking me if I was willing. Grudgingly, I followed him, moving between the trunks of huge old-growth trees that thrust up through the sharply slanting snow. I fell once and slid on my back for a good thirty feet before ramming into a tree trunk and stopping. When I got untangled and on my feet and got most of a new load of snow out of my body crevices, I looked between the tree trunks and saw Dave fifty feet below me on a snow ledge. He was grinning from ear to ear. I hurried down to join him.

The ledge itself turned out to be about midway down the falls, which–Glory Hallelujah!–were a good fifty or sixty feet tall. Here’s what we saw. Above is a picture I took of Dave on my cell phone to match the one he took of me that’s at the top of this post. All you can see behind us is the top twenty feet or so of the falls. It was impossible to get a full-length shot of the falls without the risk of crumbling our snow ledge and plunging twenty-five feet down into the stream. Given that would mean certain death by hypothermia, we were not interested. Still we could crane our necks and look around that snow mound behind us to see that, yes indeed, I had been right 37 years before, there was a fifty-foot waterfall here, free-falling into a deep plunge pool.

PlungeOneDave said, “I imagine these falls really roar with the spring runoff!” Click any of these photos for a closer view.

Here’s a photo of that plunge pool. The log lying in it is about five feet thick.

On the left you can see the foam stirred up by the impact of the falling water on the pool. The snow bank made it impossible to get a good cell-phone shot from this angle, either.

PlungeTwoOne more picture. This is a view straight down from the snow ledge we were standing on. It’s about twenty-five feet down to the surface of this beautiful second plunge pool. The icicles were about twenty feet tall. The colors were just as awe-inspiring as you see here, a rainbow of colored bedrock.

Today, I’m heading back up to Sahalie Ski Lodge for another try at the Lost Falls. The weather is superb and the falls beckon. I’m going to try to get a full-length shot of the falls, which I’ll update this post with if I get it and survive. If I get a little careless up there, then this will be my last blog entry. Wish me luck.

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Blue Dawn–Daylight Savings Time Hurts

Good? Morning.Wake up, people! Daylight Savings Time is a disease, it’s not a cure! The US government’s extension of Daylight Savings Time by an additional four weeks per year during the dark days of early spring and late fall is what’s making you feel so groggy. See that black patch on the left? That’s what it looks like out your window when your alarm goes off in the morning this time of year. It doesn’t have to be that way. But I’m guessing that the benighted legislators of Washington DC are blissfully unaware of melanopsin and its profound effect on your sense of health and wellbeing.

Melanopsin? Who? What?

Sure, that’s what the DC lawmakers are probably saying. They haven’t got the foggiest notion of how the human brain wakes up in the morning. They’re too busy obsessing about when we turn on and off our lightbulbs, and now much foreign oil it takes to keep those bulbs burning. Okay. Fair enough. Daylight Savings Time decreases the number of oil barrels we import and saves us each, what? A couple bucks per month?

Now, if I were to suggest that harming your health is not worth that couple of bucks, would you be interested in hearing why?

Visual pigmentsI thought you might. That’s why I took most of this morning to read deeply into the scientific literature and brush up on my photoreceptor cell biology. Now don’t get skittish. I’m not going to barrage you with techno-mumbojumbo. Well, not too much. But let me tell you a little about what happens when you are sleeping in the wee early hours of the morning. Inside your eyes, there are some cells whose job it is to see right through your eyelids and detect the first faint traces of dawn. Those traces come into your bedroom as a bluish glow from the morning horizon, and you “see” the light before you are even awake.

Well, thanks a lot, Daylight Savings Time, for making us turn our clocks forward. And double thanks a lot for making us do it earlier in the spring than ever before, so that the pitch blackness of 5 AM occurs at 6 AM on our reset clocks. That’s early enough that the blue glow of dawn has not even started to creep across our windowsills. That lack of natural pre-dawn glow is exactly why it is so hard to crawl out of bed in winter, or in the early spring under normal–forget Daylight Savings Time–conditions.

What the legislators have done is to extend by several weeks the awful dark time of winter mornings right into spring. And they have done it by simply forcing us to “spring ahead” too soon. It’s a recipe for making us all want to “fall back” into bed.

And it is also a recipe for making us sick. Read anywhere you want to about the awful consequences of S.A.D., seasonal affective disorder. That’s the well-known human reaction to the dark days of winter when all kinds of epidemics increase, violent crimes increase, suicides increase, and well–if it’s bad, you name it.

There is a simple solution, DC lawmakers. Surrender a bit of oil-money as a health insurance policy to keep us all happier and healthier. It isn’t all about the almighty dollar, you know. Human wellbeing OUGHT to be your number one priority in DC. Remember the Declaration of Independence? That bit about the “pursuit of happiness?” Well, by extending Daylight Savings Time, I believe you have trodden directly upon that particular “inalienable right.”

So come on DC, for the health of us all, repeal Daylight Savings Time–the extension at least, if not the whole cockamamie idea that the government should control time.

Note: For too much technical information, consult this excellent review of photobiology and the effects of melanopsins, from Oxford University.

Posted in Daylight Savings Time, I Need Help, My Soapbox, Real Science | Tagged , , | 1 Comment