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More About Hydrophilicity Analysis

In addition to his ground-breaking paper on hydrophilicity analysis of proteins published in 1981, Tom has authored numerous papers describing details of hydrophilic/phobic analysis and exploring the full capabilities of these versatile techniques. The original Hopp and Woods method can be found in the first reference below.

Click the links to download pdf copies of rare or hard-to-find articles.

Hopp, T.P. and Woods, K.R. (1981) Prediction of protein antigenic determinants from amino acid sequences. Proc. Natl. Acad. Sci. USA 78, 3824-3828. pdf

Hopp, T.P. and Woods, K.R. (1983) A computer program for predicting protein antigenic determinants. Molecular Immunology 20, 483-489. pdf

Hopp, T.P. (1984) Protein antigen conformation: folding patterns and predictive algorithms; selection of antigenic and immunogenic peptides. Annali Sclavo Collana Monografica 1(2), 47-60. pdf

Hopp, T.P. (1985) Computer prediction of protein surface features and antigenic determinants. In: Molecular basis of cancer, Part B: Macromolecular recognition, chemotherapy and immunology, pp. 367-377. Rein, R. (ed.). Alan R. Liss, New York. pdf

Hopp, T.P. (1985) Prediction of protein surfaces and interaction sites from amino acid sequences. In: Synthetic peptides in biology and medicine, pp. 3-12. Alitalo, K. et al. (eds). Elsevier, Amsterdam. pdf

Hopp, T.P. (1986) Protein surface analysis: methods for identifying antigenic determinants and other interaction sites. J. Immunol. Methods 88, 1-18. pdf

Hopp, T.P. (1986) Protein interaction sites predictable by hydrophilicity analysis. Protides of the Biological Fluids 34, 59-62. pdf

Hopp, T.P. (1987) Improved hydrophilicity plotting method for membrane proteins. In: Methods in protein sequence analysis 1986, pp. 601-607. Walsh, K.A. (ed). Humana, Clifton. pdf

Woods, K.R. and Hopp, T.P. (1987) Antigen prediction from protein hydrophilicity profiles. In: Immunogenicity of protein antigens: repertoire and regulation, pp. 15-20. Sercarz, E.E. and Berzofsky, J.A. (eds.). CRC Press, Boca Raton. pdf

Hopp, T.P. (1987) Identification of protein surfaces and interaction sites by hydrophilicity analysis. In: Proteins, structure and function, pp. 437-443. L'Italien, J.L. (ed). Plenum, New York. pdf

Hopp, T.P. (1989) The use of hydrophilicity plotting procedures to identify protein antigenic segments and other interaction sites. Methods in Enzymology 178, 571-585. pdf

Hopp, T.P. (1993) Retrospective: 12 years of antigenic determinant predictions, and more. Peptide Research 6, 183-190. pdf

Hopp, T.P. (1994) Different views of protein antigenicity. Peptide Research 7, 229-231. pdf

Hopp, T.P. (1995) Evidence from sequence information that the interleukin-1 receptor is a transmembrane GTPase. Protein Science 4, 1851-1859. pdf